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33 projets européens trouvés

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 TERMINÉ 

Protein-based functional nanostructures (ProNANO)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

The precise synthesis of nano-devices with tailored complex structures and properties is a requisite for their use in nanotechnology and medicine. Nowadays, the technology for the generation of these devices lacks the precision to determine their properties, and is accomplished mostly by “trial and error” experimental approaches. Bottom-up self-assembly that relies on highly specific biomolecular ...
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 1

 TERMINÉ 

PET Imaging in Drug Design and Development (PET3D)

Date du début: 1 juin 2016, Date de fin: 31 mai 2020,

The drug development strategy currently pursued by the pharmaceutical industry worldwide is inefficient and unsustainable for the health care system. To keep the latter affordable, drug development should become more efficient and drug treatment should become more “personalized” and “rationalized”. Molecular imaging can play a pivotal role in changing the landscape of drug design/development and i ...
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 8

 TERMINÉ 

Hybrid Drug Delivery Systems upon Mesoporous Materials, Self Assembled Therapeutics and Virosomes (HYMADE)

Date du début: 1 févr. 2015, Date de fin: 31 janv. 2019,

HYMADE focuses on the development of capsules and engineered colloidal particles for drug delivery combining mesoporous colloids, the Layer by Layer (LbL) technique and virosomes. The capsules and particles have potential applications in cancer and inflammatory diseases such as rheumatoid arthritis and uveitis. The project is based on the secondments of Early Stage Researchers and Experienced Rese ...
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 5

 TERMINÉ 

Toll-Like Receptor 4 activation and function in diseases: an integrated chemical-biology approach. (TOLLerant)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

Based on an international team derived from the COST action BM1003 (www.cost-bm1003.info, 2011-2014) and thus relying on consolidated group interactions and synergies and on a unique combination of chemistry, biology, biophysics, biochemistry and pharmacology expertise, the TOLLerant project aims to gain information on molecular aspects of TLR4 activation and signaling by using synthetic and natur ...
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 10

 TERMINÉ 

Development of Selective Carbohydrate Immunomodulators Targeting C-type Lectin Receptors on Antigen Presenting Cells (IMMUNOSHAPE)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

IMMUNOSHAPE aims at training a new generation of scientists that will be capable of combining state of the art synthesis and screening technology to develop new lead structures for highly selective glycan based multivalent immunotherapeutics for the treatment of cancer, autoimmune diseases and allergy. To this end, we have set up a training program in a unique academic-industrial environment that ...
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 17

 TERMINÉ 

Chiral Plasmons in Protein-Nanoparticle Hybrid Materials for Application as Biosensors (CINMAB)

Date du début: 20 oct. 2016, Date de fin: 19 oct. 2018,

The real challenge in the field of nanomaterials is to fabricate hybrid systems that can function as smart materials in a wide variety of applications. Hybrid systems possessing protein templates can be potential candidates in this direction due to the wide variety of applications possible in biological systems. The project outlined below aims at the synthesis of novel hybrid conjugates based on p ...
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 1

 TERMINÉ 

Graphene-based disruptive technologies (GrapheneCore1)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2018,

This project is the second in the series of EC-financed parts of the Graphene Flagship. The Graphene Flagship is a 10 year research and innovation endeavour with a total project cost of 1,000,000,000 euros, funded jointly by the European Commission and member states and associated countries. The first part of the Flagship was a 30-month Collaborative Project, Coordination and Support Action (CP-CS ...
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 158

 TERMINÉ 

Hierarchical Functionalization of Graphene for Multiple device fabrication (HIGRAPHEN)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2018,

"This project is based on the application of layer-by-layer (LbL) technology for the development of a versatile and generic procedure for the fabrication of hybrid devices involving graphene and materials of a different nature such as polymeric, organic, and inorganic entities. The project aims to achieve the organization and integration of graphene sheets with heterogeneous components of differ ...
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 2

 TERMINÉ 

Nanotherapeutics to Treat Antibiotic Resistant Gram-Negative Pneumonia Infections (PNEUMONP)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2017,

The main objective of PneumoNP is the development of a theragnostic system for the treatment of lung Gram-negative bacterial infections. As a proof of concept PneumoNP will focus the attention on Klebsiella pneumoniae caused infections. A diagnostic kit will be developed to enable a rapid and precise identification of the bacteria strain causing the infection and avoid the use of wide spectrum a ...
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 11

 TERMINÉ 

Biomolecular Hydrogels – from Supramolecular Organization and Dynamics to Biological Function (JELLY)

Date du début: 1 déc. 2012, Date de fin: 30 nov. 2017,

Certain proteins and glycans self-organize in vivo into soft and strongly hydrated, dynamic and gel-like supramolecular assemblies. Among such biomolecular hydrogels are the jelly-like matrix that is formed around the egg during ovulation, mucosal membranes, slimy coats produced by bacteria in biofilms, and the nuclear pore permeability barrier.Even though biomolecular hydrogels play crucial roles ...
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 2

 TERMINÉ 

Plasmonic Heaters Linked to Lanthanide-Based Nanothermometers for Photodynamic Therapy in the Near-Infrared (PHELLINI)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2017,

This project addresses the quest of new materials and approaches that nanotechnology requires to solve the current limitations of medicine. The potential to externally activate and control cellular processes inside the body by using light, or even to carry out treatments through drug delivery, photothermal and photodynamic therapies becomes a reality thanks to the use of especially tailored biocom ...
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 1

 TERMINÉ 

Design of a versatile and fast colloidal sensor based on virus modified particles (VIROMA)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,

"Viroma project aims to fabricate multiplexed bead-based arrays as sensing devices on the basis of virus capsid and virosome Layer by Layer-assisted assembly on colloidal carriers. The virosome based platform technology will be suitable for the detection of several analytes ranging from comparatively small molecules, of the size of dioxins to larger biomolecules such as small proteins. Such syst ...
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 4

 TERMINÉ 

System for the efficient and non-invasive harvesting and RElease of ADherent CELLs controlled by light (READCELL)

Date du début: 1 mai 2016, Date de fin: 31 oct. 2017,

The Biopharmaceuticals market is currently valued at about 150,000 million euros with an annual growth rate of 6 %. Biopharmaceutical products are mainly obtained from cells cultured in contained systems. Adherent cells represent an important share of the cell types used in production processes and are the major source of cell therapy products. Productivity of current processes for adherent cells ...
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 1

 TERMINÉ 

NanoBio-inorganic generators for conversion of renewable chemical energy into electricity (NANOBIOENER)

Date du début: 7 juil. 2015, Date de fin: 6 juil. 2017,

Focused in the secure, clean and efficient energy challenges of Horizon 2020, NANOBIOENER (this project) proposes the development of novel bio-inorganic nanogenerators which produce electricity from renewable fuels. These systems are presented as an alternative to electrochemical-based fuel cells in order to generate electrical energy in an autonomously and efficient manner. In this context, a new ...
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 1

 TERMINÉ 

Biological Foundation for the Safety Classification of Engineered Nanomaterials (ENM): Systems Biology Approaches to Understand Interactions of ENM with Living Organisms and the Environment (NANOSOLUTIONS)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2017,

The main objective of this research proposal is to identify and elaborate those characteristics of ENM that determine their biological hazard potential. This potential includes the ability of ENM to induce damage at the cellular, tissue, or organism levels by interacting with cellular structures leading to impairment of key cellular functions. These adverse effects may be mediated by ENM-induced a ...
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 40

 TERMINÉ 

Development of plasmonic quorum sensors for understanding bacterial-eukaryotic cell relations (PLASMAQUO)

Date du début: 1 mars 2011, Date de fin: 28 févr. 2017,

"This proposal aims at the development of novel nanostructured materials based on crystalline assemblies of anisotropic plasmonic (gold/silver) nanoparticles, to be used for the surface enhanced Raman scattering (SERS) detection of quorum sensing (QS) signaling molecules, and to the demonstration of applications of such materials to monitor population kinetics in bacterial colonies and the determi ...
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 2

 TERMINÉ 

Novel Upconversion Nanomaterials for Inorganic Photoactivated Chemotherapy (UCnanomat4iPACT)

Date du début: 15 janv. 2013, Date de fin: 14 janv. 2017,

Upconversion nanoparticles (UCNPs) have outstanding optical and magnetic properties, which make them extremely suited for application in cancer phototherapy and imaging. They efficiently convert low energy near infrared (NIR) light to higher energies in the visible. The so-generated upconverted luminescence can be exploited to photoactive anticancer metal complexes, a promising class of compounds ...
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 1

 TERMINÉ 

Translocation and Safe Design of Surface Engineered Metal oxide Nanoparticles (BRASINOEU)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,

"BRASINOEU aims to study the translocation and nanosafety issues of engineered metal oxide nanoparticles (NPs).The new scientific and technology developments of nanotechnology require a deeper knowledge of the effects of nanotechnology based products on human health. This knowledge is fundamental for the development of nanotechnology and to achieve its full acceptance. The concept of “safe by desi ...
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 7

 TERMINÉ 

Self-Assembly in Confined Space (SACS)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

Supramolecular chemistry studies chemistry beyond individual molecules, where molecules or macromolecules form larger entities by spontaneous self-assembly or by self-organisation. The resulting supramolecular architectures are held together by covalent bonds and a variety of non-covalent intermolecular interactions (hydrogen bonding, metal coordination, hydrophobic interactions etc). Spatially, t ...
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 10

 TERMINÉ 

Innovative Radiochemistry to Advance Molecular Imaging (RADIOMI)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

The RADIOMI Initial Training Network (ITN) has the goal of providing training in a superbly suited academic and industrial environment uniquely equipped to conduct a scientific research program that addresses one of the key aspects of functional imaging, the underpinning radiochemistry essential for preparation of radiotracers currently difficult or not possible to access. This will be exploited f ...
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 9

 TERMINÉ 

European Soft Matter Infrastructure (ESMI)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,

The central objective of this ESMI proposal is to create a top-level interdisciplinary research infrastructure available to a broad European materials research community. This is of crucial importance to the EU in view of the European strategy for nanosciences and nanotechnology and its implementation report that identifies “a lack of leading interdisciplinary infrastructures”.ESMI offers the mos ...
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 18

 TERMINÉ 

Self-assembled virus-like vectors for stem cell phenotyping (SAVVY)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2015,

The Self-Assembled Virus-like Vectors for Stem Cell Phenotyping (SAVVY) project relies on hierarchical, multi-scale assembly of intrinsically dissimilar nanoparticles to develop novel types of multifunctional Raman probes for analysis and phenotyping of heterogeneous stem cell populations.Our project will address a large unmet need, as stem cells have great potential for a broad range of therapeut ...
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 8

 TERMINÉ 

A pan-European infrastructure for quality in nanomaterials safety testing (QUALITYNANO)

Date du début: 1 févr. 2011, Date de fin: 31 juil. 2015,

Nanoscale objects interact with living organisms in a fundamentally new manner, ensuring that a fruitful marriage of nanotechnology and biology will long outlast short term imperatives. Therefore, investment in an infrastructure to drive scientific knowledge of the highest quality will have both immediate benefits of supporting the safety assessment of legacy nanomaterials, as well as pointing tow ...
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 33

 TERMINÉ 

Combined Highly Active Anti-retroviral Microbicides (CHAARM)

Date du début: 1 janv. 2010, Date de fin: 30 juin 2015,

This proposal is for a large scale collaborative project in which we propose both to develop novel microbicides directed against new intracellular targets and to investigate novel combinations of highly active anti-retroviral drugs which may be particularly effective as microbicides. Combinations may enhance efficacy but equally importantly will increase the genetic barrier to the development of r ...
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 34

 TERMINÉ 

"Combining supramolecular chemistry, physico-chemical characterization and theoretical modeling to understand multivalent interactions at the cell-hyaluronan matrix interface" (CELLMULTIVINT)

Date du début: 15 mars 2012, Date de fin: 14 mars 2015,

"Multivalent interactions are characterized by the simultaneous binding of multiple ligands on one entity to multiple receptors on another. Multivalency provides the basis for mechanisms of both agonizing and antagonizing biological interactions that are fundamentally different from those available in monovalent systems. Even though multivalent interactions occur broadly in biological systems, the ...
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 1

 TERMINÉ 

A Modular Nanosystems Platform for Advanced Cancer Management: Nano-vehicles; Tumor Targeting and Penetration Agents; Molecular Imaging, Degradome based Therapy (SAVEME)

Date du début: 1 mars 2011, Date de fin: 28 févr. 2015,

SaveMe project will address current urgent needs for pancreatic cancer diagnosis and treatment by exploiting partners’ expertise and most recent research achievements for the design and development of novel modular nanosystems platform integrating new functionalized nano-core particles and active agents. The modular platform will enable the design of diverse active nanosystems per diagnostic or th ...
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 23

 TERMINÉ 

The nuclear pore permeability barrier – physical concepts and a biosynthetic approach to understand and exploit the unique selectivity of a natural macromolecular sieve (Nuclear Pore)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2015,

Nuclear pore complexes (NPCs) are the exclusive gate of entry/exit of macromolecules into and out of the nucleus of living cells. They exhibit a unique selectivity in transport, with respect to size and molecular species: very small molecules can diffuse efficiently through the pore, while larger objects are delayed/blocked unless they are bound to specialized proteins, so called nuclear transport ...
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 1

 TERMINÉ 

Regenerable active polyelectrolyte nanofiltration membranes for water reuse and metal/acid recovery (LbLBRANE)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2015,

The shortage of drinking water in many regions on the planet constitutes a real problem and hazard. The use of seawater, brackish water and wastewater for human consumption is not a new concept. In spite of the success of membrane technology in water reclamation, membrane separation systems suffer from a serious problem: membrane fouling. The main downside is an inevitabe increase in operation and ...
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 13

 TERMINÉ 

Design of Novel Polyelectrolyte Multilayer Based Delivery Systems for Therapeutic Antibodies and siRNA (DesiRNA)

Date du début: 1 juin 2010, Date de fin: 31 mai 2014,

The design and fabrication of biocompatible carrier systems for RNA based medicine and therapeutic antibodies equipped with multiple functions suitable for controlled and targeted delivery is the main scope of this proposal. General strategies for the encapsulation and release of RNA and proteins will be developed on the basis of the Layer by Layer technique (LBL) employing core materials tailored ...
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 3

 TERMINÉ 

Transport studies on polymer based nanodevices and assemblies for delivery and sensing (TrasNade)

Date du début: 1 déc. 2010, Date de fin: 31 mai 2014,

TRANSNADE is designated for the study of the transport properties of nanoscale assemblies and devices fabricated from polymers and polyelectrolytes, such as polyelectrolyte multilayers, polyelectrolyte brushes, polymer micelles, and polymersomes. Transport properties are fundamental for the rational design of delivery devices since the mechanism of transport will finally define release properties. ...
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 2

 TERMINÉ 

Development of a high sensitive and specific nanobiosensor based on surface enhanced vibrational spectroscopy dedicated to the in vitro proteins detection and disease diagnosis (Nanoantenna)

Date du début: 1 oct. 2009, Date de fin: 31 mars 2013,

The main goal of our proposal is to develop a novel optical nanobiosensor based on extraordinary vibrational signal enhancement of the proteins to be detected. To reach vibrational signal enhancement, we will exploit the optical properties of specially designed metallic nanoparticles which should act as nanoantenna and the associated field enhancement to obtain a direct detection of proteins bound ...
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 13

 TERMINÉ 

Health Impact of Engineered Metal and Metal Oxide Nanoparticles: Response, Bioimaging and Distribution at Cellular and Body Level (HINAMOX)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2012,

Metal oxide and metal NPs are particularly dangerous for two reasons: their special catalytic activity coming from the properties of their nanointerface may interfere with numerous intracellular biochemical processes and the decomposition of NPs and the ion leakage could heavily interfere with the intracellular free metal ion homeostasis, which is essential for cell metabolism. A very specific pro ...
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 9

 TERMINÉ 

Development of carbohydrate array technology to systematically explore the functional role of glycans in healthy and diseased states (EuroGlycoArrays)

Date du début: 1 sept. 2008, Date de fin: 31 août 2012,

The development and production of glycoarrays will provide the foreground knowledge necessary to lead to a step change in the diagnosis and treatment of diseases ranging from cancers to autoimmune diseases. Carbohydrates play a pivotal role in the molecular interactions that govern biological events at the centre of health and disease. This has become more evident as the characterisation and ident ...
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 17