Plus de 40 projets européens trouvés
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TERMINÉ
A Systems medicine approach to chronic inflammatory disease (SYSCID)
Date du début: 1 janv. 2017, Date de fin: 31 mars 2022,
"The SYSCID consortium aims to develop a systems medicine approach for disease prediction in CID. We will focus on three major CID indications with distinct characteristics, yet a large overlap of their molecular risk map: inflammatory bowel disease, systemic lupus erythematodes and rheumatoid arthritis. We have joined 15 partners from major cohorts and initiatives in Europe (e.g.IHEC, ICGC, Twins...
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16
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TERMINÉ
Healthy minds from 0-100 years: Optimising the use of European brain imaging cohorts (Lifebrain)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,
Our main objective is to identify determinants of brain, cognitive and mental health at different stages of life. By integration, harmonisation and enrichment of major European neuroimaging studies of age differences and changes, we will obtain an unparalleled database of fine-grained brain, cognitive and mental health measures of more than 6.000 individuals. Longitudinal brain imaging, genetic an...
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16
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TERMINÉ
Multiple manifestations of genetic and non-genetic factors in Multiple Sclerosis disentangled with a multi-omics approach to accelerate personalised medicine (MultipleMS)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,
The complex interactions between genetic and non-genetic factors produce heterogeneities in patients as reflected in the diversity of pathophysiology, clinical manifestations, response to therapies, disease development and progression. Yet, the full potential of personalized medicine entails biomarker-guided delivery of efficient therapies in stratified patient populations.MultipleMS will therefor...
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25
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TERMINÉ
Functional Systems of Capsules (FunCapSys)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,
The simplest living organism is composed of myriad chemical subsystems, each consisting of structurally complex biomolecules that interact in many ways; the properties of life emerge from these dense connections. Understanding how these interactions take place will help elucidate the foundations of biology, as well as enabling the design and creation of new chemical networks with targeted function...
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1
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TERMINÉ
Global Methods in the Langlands Program (GMLP)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,
The Langlands program is a conjectural framework for understanding the deep relations between automorphic forms and arithmetic. It implies a parameterization of representations of Galois groups of (local or global) fields in terms of representations of (p-adic or adelic) reductive groups. While making progress in the Langlands program often means overcoming significant technical obstacles, new res...
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1
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TERMINÉ
An Optical Quasicrystal for ultracold atoms (Quasicrystal)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,
During the last fifteen years, ultracold atoms in optical lattices have emerged as a powerful model system to study the many-body physics of interacting particles in periodic potentials. The main objective of this proposal is to extend this level of control to quasiperiodic potentials by realizing an optical quasicrystal.Quasicrystals are a novel form of condensed matter that is non-periodic, but ...
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1
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TERMINÉ
CLONAL AND CELLULAR HETEROGENEITY OF BREAST CANCER AND ITS DYNAMIC EVOLUTION WITH TREATMENT (CLONCELLBREAST)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,
CLONAL AND CELLULAR HETEROGENEITY OF BREAST CANCER AND ITS DYNAMIC EVOLUTION WITH TREATMENTBreast cancer remains one of the leading causes of cancer death in women. One of the greatest challenges is that breast cancer is a heterogeneous group of 10 diseases defined by genomic profiling. In addition, each tumor is composed of clones and clonal evolution underpins the successive acquisition of the h...
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1
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TERMINÉ
Exploring the Chemical Biology of Sequence Space via Picoliter Droplets (PicoCB)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,
Directed evolution of functional proteins has arguably emerged as an approach to protein engineering that can complement or better design-led approaches to protein function. However, as a random process, enormous numbers of variants have to be screened and selected to have a chance to identify successful catalysts. This process is costly and cumbersome: Industrial screening facilities require inve...
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1
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TERMINÉ
Extending the range of the glassy state: Exploring structure and property limits in metallic glasses (ExtendGlass)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,
Metallic glasses (MGs), among the most actively studied metallic materials, have attractive mechanical properties (high elastic limit) but show work-softening and lack ductility. Recent work suggests the as-cast state of MGs can be much altered by thermomechanical treatments: rejuvenation (to higher energy) offers improved plasticity (perhaps even desirable work-hardening); relaxation (to lower en...
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1
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TERMINÉ
The Impact of the Ancient City (ImpAncCit)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,
The aim of the project is to re-examine the impact of urbanism in the Greco-Roman Mediterranean on subsequent urban history, both locally, in the impact of individual cities that survive into modern times on their development, and globally in the impact of ideas of ancient urbanism derived both from writings and the visible remains of ancient cities on urban formation and development, both within ...
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1
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TERMINÉ
Resolving subglacial properties, hydrological networks and dynamic evolution of ice flow on the Greenland Ice Sheet (RESPONDER)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,
The Greenland Ice Sheet is losing mass at a growing rate and has since 2010 caused sea level rise of 1 mm/year. The most severe changes occur in the drainage basins of marine-terminating glaciers, which flow rapidly and drain 88% of the ice sheet. The latest report by the Intergovernmental Panel on Climate Change concluded that the widespread acceleration of these glaciers in recent years was a re...
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2
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TERMINÉ
Empirical Demand and Welfare Analysis (EDWEL)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,
Measurement of consumer welfare is central to economic evaluations. It underlies calculation of price-indices, formulation of tax policies, and environmental and industrial regulation. But existing measurement methods rely on restrictive assumptions about consumer preferences, leading to potentially incorrect conclusions regarding policy-impacts. The proposed project aims to make fundamental contr...
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1
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TERMINÉ
A Minimal-Tag Bioorthogonal Labelling Approach to Protein Uptake, Traffic and Delivery (TagIt)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,
The ability to probe dynamic cellular events that involve disease-associated proteins is limited, to a large extent, by the lack of development of a strategy that can use small coupling partners to react in chemoselective fashion with rapid kinetics that does not interfere with biological function(s) and localisation. In this application, I describe a conceptually new bioorthogonal-labelling appro...
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1
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TERMINÉ
Synthesizing Meiotic Crossover Hotspots in Arabidopsis (SynthHotSpot)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,
The majority of eukaryotes reproduce sexually via meiosis. During meiosis homologous chromosomes pair and undergo reciprocal genetic exchange termed crossover. Meiotic recombination is a major evolutionary force and has a profound effect on patterns of genetic diversity in sexual species. Crossovers distributions are highly non-random and are typically focused in narrow hotspots. Study of hotspots...
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1
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TERMINÉ
Semi-Artificial Photosynthesis with Wired Enzymes (MatEnSAP)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,
Nature has been harnessing solar energy to drive endergonic life-sustaining reactions such as photosynthesis for billions of years. However, the overall biological processes are inefficient despite the evolution of efficient enzymes for carrying out specific reactions. Currently, there is an urgent need to develop superior strategies for the large scale conversion of solar energy into a renewable ...
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1
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TERMINÉ
Industrialisation and Urban Growth from the mid-nineteenth century Ottoman Empire to Contemporary Turkey in a Comparative Perspective, 1850-2000 (UrbanOccupationsOETR)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,
This project aims to overcome historiographical and disciplinary limitations in social and economic history, historical geography and urban studies for the Ottoman Empire and the Republic of Turkey. The chosen long-term Ottoman/Turkish perspective is intended to facilitate comparative approaches so as to overcome the limitations of national historiographies. By extending the analysis up to 2000 th...
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2
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TERMINÉ
Star formation quenching and feedback in galaxies throughout the cosmic epochs (QUENCH)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,
"Throughout the whole life of the universe only 4% of the baryons have been converted into stars, implying that some physical processes must be responsible for suppressing star formation in galaxies. Within this context, one of the most hotly debated open questions is the identification of the process responsible for quenching star formation in galaxies and transforming them into passive and quies...
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1
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TERMINÉ
New level of theoretical precision for LHC Run 2 and beyond (NNLOforLHC2)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,
LHC Run 2 will operate at significantly higher centre of mass energy and could offer an unprecedented insight into the largely unexplored region of TeV physics. The usefulness of this wealth of forthcoming high-quality data would, however, be strongly dependent on the availability of theoretical predictions with matching accuracy. The current state of the art for hadron collider calculations is NN...
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1
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TERMINÉ
Regulation and Evolution of C4 photosynthesis (Revolution)
Date du début: 1 sept. 2016, Date de fin: 31 août 2021,
Life is dependent on sugars made during photosynthesis. When plants colonized land ~450 million years ago they used a photosynthetic system known as the C3 pathway that still operates in the majority of species today. However, from ~30 million years ago over sixty plant lineages evolved a version of photosynthesis known as the C4 pathway that increases CO2 fixation efficiency by about 50%. C4 spec...
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1
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TERMINÉ
Advanced Spectroscopy and Spectrometry for Imaging Metabolism using Isotopically-Labeled Endogenous Substrates (ASSIMILES)
Date du début: 1 sept. 2016, Date de fin: 31 août 2021,
A technological revolution is currently taking place making it possible to noninvasively study metabolism in mammals (incl. humans) in vivo with unprecedented temporal and spatial resolution. Central to these developments is the phenomenon of hyperpolarization, which transiently enhances the magnetic resonance (MR) signals so much that real-time metabolic imaging and spectroscopy becomes possible....
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1
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TERMINÉ
Oscillatory Rhythmic Entrainment and the Foundations of Language Acquisition (BABYRHYTHM)
Date du début: 1 sept. 2016, Date de fin: 31 août 2021,
Half of “late talkers”, infants who are not yet speaking by 2 years of age, will go on to develop language impairments. Currently, we have no reliable means of identifying these infants. Here we combine our developmental approach to phonology (psycholinguistic grain size theory), to the neural mechanisms underlying speech encoding (temporal sampling [TS] theory) and our work on the developmental i...
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1
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TERMINÉ
The Physical Mechanics of Swimming Bacteria (PhyMeBa)
Date du début: 1 sept. 2016, Date de fin: 31 août 2021,
Bacteria play a critical role in the life of higher organisms. Their behavior is constrained by the physical properties of their habitat: first and foremost, the presence of a surrounding fluid. Most bacteria are motile, and most motile bacteria swim in fluids using slender helical appendages called flagella rotated by specialized motors. While many bacteria have only one flagellum, most well-stud...
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1
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TERMINÉ
Analysis and control of large scale heterogeneous networks: scalability, robustness and fundamental limits (HetScaleNet)
Date du début: 1 août 2016, Date de fin: 31 juil. 2021,
The proposed research will make a contribution towards the analysis and synthesis of large scale complex networks: fundamental theory will be developed and important applications will be addressed, by extending tools from control theory. Networks are present throughout the physical and biological world, but nowadays they also pervade our societies and everyday lives. Major challenges that will be ...
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1
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TERMINÉ
Situating Free Speech: European parrhesias in comparative perspective (SFS)
Date du début: 1 juin 2016, Date de fin: 31 mai 2021,
Recent tragic events in France and Denmark, and the debates and reactions which have followed them, have once again brought centre stage enduring questions surrounding ‘free speech’ in contemporary Europe: when and how can speech be ‘free’? With what consequences? Why and how does this come to matter differently to people in particular social and historical contexts? And what, if anything, is dist...
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1
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TERMINÉ
Less is more: Single Cell Analysis of Zebrafish Blood Development (ZF_Blood)
Date du début: 1 mai 2016, Date de fin: 30 avr. 2021,
Blood stem cells need to both perpetuate themselves (self-renew) and differentiate into all mature blood cells to maintain blood formation throughout life. However, it is unclear how the underlying gene regulatory network maintains this population of self-renewing and differentiating stem cells, and how it accommodates the transition from a stem cell to a mature blood cell. Our current knowledge o...
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1
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TERMINÉ
Identification of regulatory signals from vascular niche in alveolar regeneration and pulmonary fibrosis (Niche Fibrosis)
Date du début: 1 mai 2016, Date de fin: 30 avr. 2021,
Pulmonary fibrosis is a multifaceted and fatal disease that includes damaged alveolar epithelial cells and disorganization of multiple stromal cells. Dysregulation of multicellular crosstalk between epithelial and stromal cells is likely to contribute to fibrosis. However, the precise way this tissue damage occurs is unknown. I hypothesize that impaired function of lung epithelial stem cell lead t...
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1
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TERMINÉ
Quantum Gas in a Box (QBox)
Date du début: 1 mai 2016, Date de fin: 30 avr. 2021,
"Ultracold atomic gases offer flexible systems for fundamental studies of both equilibrium and non-equilibrium many-body problems that are relevant across many fields, from condensed matter physics to high-energy physics and astrophysics. In the long run, research on these systems could also lead to practical applications, in the development of novel materials, force sensing, navigation, and quant...
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1
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TERMINÉ
Dynamics of Multiple, Interacting and Concurrent Markov Chains (DYNAMICMARCH)
Date du début: 1 mai 2016, Date de fin: 30 avr. 2021,
Markov chains are fundamental processes and have been studied in nearly every scientific discipline in the past 100 years. In computer science, reversible Markov chains, also known as random walks, form the basis of many efficient randomised algorithms which have been successfully applied to a variety of complex sampling, learning and optimisation problems.Nowadays an increasing number of algorith...
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1
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TERMINÉ
Contexts of and Relations between Early Writing Systems (CREWS)
Date du début: 1 avr. 2016, Date de fin: 31 mars 2021,
Contexts of and Relations between Early Writing SystemsThis project takes an innovative and interdisciplinary approach to the history of writing, redressing lingering problems that have hampered previous research and developing new methodologies for studying scripts and their social context. The staff on the project will work on specific case studies relating to inscriptions of the ancient Aegean,...
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1
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TERMINÉ
Training Network to Understand and Exploit Mechanisms of Sensory Perception in Bacteria (PATHSENSE)
Date du début: 1 avr. 2017, Date de fin: 31 mars 2021,
The PATHSENSE (Pathogen Sensing) ETN will bring together an interdisciplinary team of world-leading researchers from Europe to tackle a highly ambitious scientific project, focusing on the molecular mechanisms of sensory perception in bacterial pathogens. PATHSENSE will establish an innovative doctoral training programme that will deliver 13 PhD graduates and high-impact scientific outputs. The re...
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14
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TERMINÉ
Barocaloric materials for energy-efficient solid-state cooling (BCOOL)
Date du début: 1 avr. 2016, Date de fin: 31 mars 2021,
Cooling is essential for food and drinks, medicine, electronics and thermal comfort. Thermal changes due to pressure-driven phase transitions in fluids have long been used in vapour compression systems to achieve continuous refrigeration and air conditioning, but their energy efficiency is relatively low, and the working fluids that are employed harm the environment when released to the atmosphere...
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1
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TERMINÉ
Diplomatic Face-Work - between confidential negotiations and public display (DIPLOFACE)
Date du début: 1 avr. 2016, Date de fin: 31 mars 2021,
The rise of social media, coupled with intensifying demands for more transparency and democracy in world politics, brings new challenges to international diplomacy. State leaders and diplomats continue to react to traditional media, but now also attempt to present themselves proactively through tweets, public diplomacy and nation branding. These efforts often take place simultaneously and sometime...
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2
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TERMINÉ
Directed Protein Evolution for Synthetic Biology and Biocatalysis (ES-Cat)
Date du début: 1 mars 2017, Date de fin: 28 févr. 2021,
ES-Cat will use directed evolution as a tool to reproduce Nature's remarkable ability to generate molecular machines - in particular enzymes – that perform at levels near perfection. Instead of seeing rational and combinatorial approaches as alternatives, we combine them in this network to achieve a ‘smarter’ and more efficient exploration of protein sequence space. By harnessing the forces of Dar...
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11
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TERMINÉ
Optical Infrared Coordination Network for Astronomy (OPTICON)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
Europe has become a global leader in optical-near infrared astronomy through excellence in space and ground-based experimental and theoretical research. While the major infrastructures are delivered through major national and multi-national agencies (ESO, ESA) their continuing scientific competitiveness requires a strong community of scientists and technologists distributed across Europe’s nations...
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34
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TERMINÉ
TRANSlating the role of Mitochondria in Tumorigenesis (TRANSMIT)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
The consolidation of the knowledge that cancer is not only a genetic, but also a metabolic disease, has led scientists to investigate the intricate metabolic plasticity that transformed cells must undergo to survive the adverse tumor microenvironment conditions, and the contribution of oncogenes and tumor suppressors in shaping metabolism. In this scenario, genetic, biochemical and clinical eviden...
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10
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TERMINÉ
Catalyst Cascade Reactions in ‘One-Flow’ within a Compartmentalized, Green-Solvent ‘Digital Synthesis Machinery’ – End-to-End Green Process Design for Pharmaceuticals (One-Flow)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
"ONE-FLOW translates ‘vertical hierarchy’ of chemical multistep synthesis with its complex machinery into self-organising ‘horizontal hierarchy’ of a compartmentalized flow reactor system – a biomimetic digital flow cascade machinery with just one reactor passage. To keep horizontal hierarchy manageable, orthogonality among the consecutive reactions needs to be increased. The winning point of natu...
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8
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TERMINÉ
Synaptic dysfunction in Neurodegenerative Diseases (SYNDEGEN)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
Neurodegenerative diseases (NDDs) of aging are a growing burden on societies. Although studies on the degeneration of neurons have been a main focus of research, increasing evidence points to synapses as the site where Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD) begin. There is growing evidence that synapses are sites of early and aberrant protein misfolding, a...
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8
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TERMINÉ
Multi-phase Lattice Materials (MULTILAT)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,
The integration of materials and architectural features at multiple scales into structural mechanics changed the way buildings were designed and gave us the Eiffel Tower, for example. This approach led to the development of computational design approaches used in modern day construction and it is believed that similar principles can be applied to the design and manufacture of new lattice-based mi...
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1
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TERMINÉ
Training European Experts in Multilevel Bioimaging, Analysis and Modelling of Vertebrate Development and Disease (ImageInLife)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
This proposal sprang from European scientists in both academia and industry who identified a common challenge: setting up a training frame to educate the next generation of imagers in complex biological systems (healthy & pathological), so they are able to master all major aspects of this competitive field and bring important innovations to universities and companies.The long-term goal of any init...
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11
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TERMINÉ
The Post-crisis Legitimacy of the European UnionEuropean Training Network (PLATO)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
Is there a crisis in the legitimacy of the European Union? That research question is timely and important. Investigating it is also an ideal way of training research leaders of tomorrow to rethink our assumptions about the study of legitimate political order. Whilst, however, the financial crisis has raised new questions about the legitimacy of the EU, existing theories of legitimacy crises are la...
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